476 research outputs found
Multiscale 3D Shape Analysis using Spherical Wavelets
©2005 Springer. The original publication is available at www.springerlink.com:
http://dx.doi.org/10.1007/11566489_57DOI: 10.1007/11566489_57Shape priors attempt to represent biological variations within a population. When variations are global, Principal Component Analysis (PCA) can be used to learn major modes of variation, even from a limited training set. However, when significant local variations exist, PCA typically cannot represent such variations from a small training set. To address this issue, we present a novel algorithm that learns shape variations from data at multiple scales and locations using spherical wavelets and spectral graph partitioning. Our results show that when the training set is small, our algorithm significantly improves the approximation of shapes in a testing set over PCA, which tends to oversmooth data
Special issue on MICCAI 2018
status: publishe
Guest Editorial: IJCARS-MICCAI 2018 special issue.
status: publishe
3D functional models of monkey brain through elastic registration of histological sections
In this paper we describe a method for the reconstruction and visualization of functional models of monkey brains. Models are built through the registration of high resolution images obtained from the scanning of histological sections with reference photos taken during the brain slicing. From the histological sections it is also possible to acquire specifically activated neuron coordinates introducing functional information in the model. Due to the specific nature of the images (texture information is useless and the sections could be deformed when they were cut and placed on glass) we solved the registration problem by extracting corresponding cerebral cortex borders (extracted with a snake algorithm), and computing from their deformation an image transform modeled as an affine deformation plus a non-linear field evaluated as an elastically constrained deformation minimizing contour distances. Registered images and contours are used then to build 3D models of specific brains by a software tool allowing the interactive visualization of cortical volumes together with the spatially referenced neurons classified and differently colored according to their functionalities
Multilinear Wavelets: A Statistical Shape Space for Human Faces
We present a statistical model for D human faces in varying expression,
which decomposes the surface of the face using a wavelet transform, and learns
many localized, decorrelated multilinear models on the resulting coefficients.
Using this model we are able to reconstruct faces from noisy and occluded D
face scans, and facial motion sequences. Accurate reconstruction of face shape
is important for applications such as tele-presence and gaming. The localized
and multi-scale nature of our model allows for recovery of fine-scale detail
while retaining robustness to severe noise and occlusion, and is
computationally efficient and scalable. We validate these properties
experimentally on challenging data in the form of static scans and motion
sequences. We show that in comparison to a global multilinear model, our model
better preserves fine detail and is computationally faster, while in comparison
to a localized PCA model, our model better handles variation in expression, is
faster, and allows us to fix identity parameters for a given subject.Comment: 10 pages, 7 figures; accepted to ECCV 201
Generative discriminative models for multivariate inference and statistical mapping in medical imaging
This paper presents a general framework for obtaining interpretable
multivariate discriminative models that allow efficient statistical inference
for neuroimage analysis. The framework, termed generative discriminative
machine (GDM), augments discriminative models with a generative regularization
term. We demonstrate that the proposed formulation can be optimized in closed
form and in dual space, allowing efficient computation for high dimensional
neuroimaging datasets. Furthermore, we provide an analytic estimation of the
null distribution of the model parameters, which enables efficient statistical
inference and p-value computation without the need for permutation testing. We
compared the proposed method with both purely generative and discriminative
learning methods in two large structural magnetic resonance imaging (sMRI)
datasets of Alzheimer's disease (AD) (n=415) and Schizophrenia (n=853). Using
the AD dataset, we demonstrated the ability of GDM to robustly handle
confounding variations. Using Schizophrenia dataset, we demonstrated the
ability of GDM to handle multi-site studies. Taken together, the results
underline the potential of the proposed approach for neuroimaging analyses.Comment: To appear in MICCAI 2018 proceeding
Federated learning enables big data for rare cancer boundary detection
Although machine learning (ML) has shown promise in numerous domains, there are concerns about generalizability to out-of-sample data. This is currently addressed by centrally sharing ample, and importantly diverse, data from multiple sites. However, such centralization is challenging to scale (or even not feasible) due to various limitations. Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here we present findings from the largest FL study to-date, involving data from 71 healthcare institutions across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, utilizing the largest dataset of such patients ever used in the literature (25,256 MRI scans from 6,314 patients). We demonstrate a 33% improvement over a publicly trained model to delineate the surgically targetable tumor, and 23% improvement over the tumor's entire extent. We anticipate our study to: 1) enable more studies in healthcare informed by large and diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further quantitative analyses for glioblastoma via performance optimization of our consensus model for eventual public release, and 3) demonstrate the effectiveness of FL at such scale and task complexity as a paradigm shift for multi-site collaborations, alleviating the need for data sharing
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